Overview

Radiation Therapy and Chemotherapy in Treating Patients With Cancer of the Pancreas or Stomach

Status:
Completed
Trial end date:
2003-05-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of radiation therapy plus chemotherapy in treating patients who have cancer of the pancreas or stomach.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Alliance for Clinical Trials in Oncology
Collaborator:
National Cancer Institute (NCI)
Treatments:
Cisplatin
Gemcitabine
Criteria
DISEASE CHARACTERISTICS: Histologically proven unresectable (including incomplete
resections) or locally recurrent pancreatic or gastric cancer No evidence of metastases
outside of the planned radiation field No cystadenocarcinoma of the pancreas or pancreatic
tumors of neuroendocrine origin

PATIENT CHARACTERISTICS: Age: 18 and over Performance Status: ECOG 0-1 Life Expectancy: Not
specified Hematopoietic: Absolute neutrophil count at least 2,000/mm3 Platelet count at
least 100,000/mm3 Hepatic: Bilirubin within normal limits Alkaline phosphatase no greater
than 3.0 times upper limit of normal (ULN) AST no greater than 3.0 times ULN Renal:
Creatinine no greater than 1.3 times ULN Other: Not pregnant or nursing Fertile patients
must use effective contraception No significant infection or medical illness No significant
nausea or vomiting At least 1200 calories per day of oral nutrition

PRIOR CONCURRENT THERAPY: Biologic therapy: No prior or concurrent biologic therapy
Chemotherapy: No prior or concurrent chemotherapy Endocrine therapy: Not specified
Radiotherapy: No prior radiotherapy (except focal fields for skin cancer that do not
overlap with planned radiotherapy fields) Surgery: At least 21 days since laparotomy
surgery