Radiation Therapy (XRT) and ZD6474 in Non-Small Cell Lung Cancer (NSCLC)
Status:
Terminated
Trial end date:
2012-09-01
Target enrollment:
Participant gender:
Summary
Primary Objectives:
- To assess the safety of oral therapy with ZD6474 by evaluating the frequency, severity,
and duration of treatment-emergent adverse events in patients with poor prognosis lung
cancer.
- To record the extent, frequency and duration of any tumor responses to this treatment
regimen and assess whether ZD6474 augments the efficacy of radiation therapy in
non-small cell lung cancer patients.
- To determine the recommended phase II dose of ZD6474 for future clinical studies with
radiation therapy.
Secondary Objectives:
- To determine the effects on metabolism and angiogenic factors by positron emission
tomography (PET) scan/computed tomography (CT) scan , vascular endothelial growth factor
(VEGF), and circulating endothelial cell levels in patients treated with ZD6474 and
radiation therapy.