Radiation Therapy Plus Thalidomide and Temozolomide in Treating Patients With Newly Diagnosed Brain Metastases
Status:
Completed
Trial end date:
2004-12-07
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. Combining
whole-brain radiation therapy with thalidomide and temozolomide may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combining whole-brain radiation therapy
with thalidomide and temozolomide in treating patients who have newly diagnosed brain
metastases.
Phase:
Phase 2
Details
Lead Sponsor:
Wake Forest Baptist Health Wake Forest University Health Sciences