Overview

Radiation Therapy Plus Hyperbaric Oxygen in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Hyperbaric oxygen may increase the effectiveness of radiation therapy. Combining hyperbaric oxygen with radiation therapy may be an effective treatment for glioblastoma multiforme. PURPOSE: Phase I/II trial to study the effectiveness of combining radiation therapy with hyperbaric oxygen in treating patients who have newly diagnosed glioblastoma multiforme.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Barrett Cancer Center
Criteria
DISEASE CHARACTERISTICS: Histologically proven newly diagnosed glioblastoma multiforme
Measurable residual tumor by MRI after biopsy or craniotomy

PATIENT CHARACTERISTICS: Age: Over 18 Performance status: Karnofsky 70-100% Life
expectancy: More than 8 weeks Hematopoietic: Not specified Hepatic: Not specified Renal:
Not specified Pulmonary: No severe pulmonary disease (e.g., emphysema with carbon dioxide
retention) No untreated pneumothorax Other: Not pregnant or nursing Negative pregnancy test
Fertile patients must use effective contraception No other malignancy within the past 5
years except epithelial skin cancer No psychological, familial, sociological, or
geographical conditions that would preclude study No intractable seizure disorder

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior or
concurrent bleomycin Endocrine therapy: Not specified Radiotherapy: No prior cranial
radiotherapy Surgery: See Disease Characteristics Other: No other prior therapy, including
adjuvant therapy, for glioblastoma multiforme