Radiation Therapy, Arsenic Trioxide, and Temozolomide in Treating Patients With Newly Diagnosed High-Grade Glioma
Status:
Completed
Trial end date:
2009-02-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in
chemotherapy, such as arsenic trioxide and temozolomide, work in different ways to stop the
growth of tumor cells, either by killing the cells or by stopping them from dividing. Arsenic
trioxide and temozolomide may also make tumor cells more sensitive to radiation therapy.
Giving radiation therapy together with combination chemotherapy may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of arsenic trioxide
when given together with temozolomide and radiation therapy in treating patients with newly
diagnosed high-grade glioma.