REsistance to Aspirin and Clopidogrel in acuTe Myocardial Infarction
Status:
Completed
Trial end date:
2015-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare 3 point-of-care methods for monitoring antiplatelet
therapy to golden standard (Light transmittance aggregometry-LTA) in high risk population of
acute myocardial infarction patients. If two methods (PFA-100, VerifyNOW,Multiplate or LTA)
will indicate insufficient antiplatelet blockade/high residual reactivity for aspirin,
clopidogrel or both, the dose of aspirin will be increased to 200mg qd and the dose of
clopidogrel will be increased to 2x75mg qd.In addition genotyping of CYP2C19 (6 alleles) will
be performed.