REMEMBER: Reducing Early Mortality & Morbidity by Empiric Tuberculosis (TB) Treatment
Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
Participant gender:
Summary
People with HIV have a high chance of becoming infected with TB, especially when they live in
areas where TB infection is common. It can be difficult to diagnose TB in people who need to
start HIV treatment right away. Within about 6 months after starting HIV treatment, some of
these people can become very sick with TB and can even die from it.
This study was being done in people who were starting HIV treatment and who lived in areas
where the TB infection rate is high. The purpose of this study was to test an experimental
approach to TB treatment to see if it is better than the usual approach. The experimental
approach was to start TB treatment at the same time as HIV treatment, even when TB infection
had not been found. The usual approach was to start TB treatment only if TB infection was
found.
In this study, half of the people started TB treatment at the same time as they started their
HIV treatment. The other half started TB treatment only if TB infection was found.
The study also tested how safe and effective it was to start TB treatment at about the same
time as HIV treatment even when TB infection had not been found. The study collected
information about diet, whether (and when) people in the study became sicker or died, how
well their HIV was controlled, how they were feeling, how they were taking their medications,
whether it mattered where they lived or what kind of HIV and TB care was standard, how many
people were diagnosed with TB while in the study, and how the cost of the two treatment
options on a national level could be compared.
Phase:
Phase 4
Details
Lead Sponsor:
AIDS Clinical Trials Group
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Efavirenz Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Ethambutol Isoniazid Isoniazid, pyrazinamide, rifampin drug combination Pyrazinamide Rifampin Tenofovir