RCT of Fixed vs Titrated Letrozole in Breast Cancer Patient Undergoing IVF
Status:
Active, not recruiting
Trial end date:
2021-09-30
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare two different ways to administer Letrozole to
determine their effectiveness in blocking estrogen production during ovarian stimulation in
patients with breast cancer prior to chemotherapy/radiotherapy so that oocytes or embryos can
be cryopreserved and patients can possibly achieve a pregnancy after the treatment of breast
cancer.
During standard ovulation stimulation, the estrogen levels will exceed normal levels and may
reach 10 times the normal level for a 2 week period. This may not be desirable in breast
cancer patients. The study hopes to determine if the investigators can stimulate oocyte
development in the conventional way and administer different doses of Letrozole as the
oocytes develop, to keep estradiol levels low, increase the number of oocytes the
investigators are able to recover, and improve the quality of those oocytes.