RCT(Randomized Clinical Trial ) of Antibiotic Therapy in Chronic Endometritis
Status:
Completed
Trial end date:
2018-12-15
Target enrollment:
Participant gender:
Summary
120 cases with a diagnosis of chronic endometritis, confirmed by the presence of plasma cells
in endometrial biopsy sample identified by immunohistochemical staining using CD138 antibody,
have been recruited. The subjects have been randomly divided into two groups, the
experimental group have been given antibiotic (Levofloxacin and Tinidazole for 14 days)
treatment, the control group did not receive any antibiotic. Initially it was planned for
women in the control group to take placebo,but the organization was difficult, so it was
changed prior to the start of the study to an open label study. A repeat endometrial biopsy
sample have been obtained 2-4 weeks after completion of the antibiotic therapy to assess the
response to treatment. The conversion rate will be compared between the two groups