RCT Mesenchymal Stem Cells Versus Hyaluronic Acid in OA Knee):

• Status: Completed
• Trial end date: 2019-02-28
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the therapeutic effect of adult autologous mesenchymal stem cells (abbreviated as MSCs) in patients with osteoarthritic knee and compare to intra articular injection of Synvisc-One.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese University of Hong Kong
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• Male and female subjects aged between 18 and < 65

• Radiological evidence of osteoarthritis with Kellgren and Lawrence grade 2 and 3

• Patients on a pain level equal to or higher than 5 on a VAS scale of 10

Exclusion Criteria:

• Previous cases of alcoholism or drug abuse

• Pregnancy and breast-feeding

• Serious pathologies such as carcinoma or autoimmune disease

• Hypersensitivity toward Hyaluorinc Acid

• Undergoing steroid-based systemic therapy or interrupted since less than 1 month

• Significant hematologic diseases

• Mechanical instability, ligamentous laxity/deficiency or gross deformity