RCT Comparing Immunosuppressive Regimens in Elderly Renal Transplant Recipients
Status:
Recruiting
Trial end date:
2026-12-01
Target enrollment:
Participant gender:
Summary
Open label, randomized, multicenter, intervention trial comparing standard immunosuppression
with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen in
combination with everolimus.
The primary objective is to test the hypothesis that an age-adapted immunosuppressive regimen
targeted at reduced immunosuppression with low calcineurin inhibitor (tacrolimus) exposure in
combination with everolimus will result in improved outcome in elderly recipients of A:
Kidneys from older deceased donors (>64 years) and B: Kidneys from living donors (all ages)
and younger deceased donors (<65 years).
Phase:
Phase 4
Details
Lead Sponsor:
University Medical Center Groningen
Collaborators:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Erasmus Medical Center Leiden University Medical Center Radboud University UMC Utrecht Universitaire Ziekenhuizen Leuven VU University Medical Center