Overview

RCT ALB for SA Cysticercosis

Status:
Withdrawn
Trial end date:
2007-06-01
Target enrollment:
0
Participant gender:
All
Summary
This study will enroll 120 individuals diagnosed with subarachnoid cysticercosis, a disease caused by the invasion of the basal part of your brain by a parasite named Taenia solium. Subarachnoid cysticercosis is usually treated with albendazole for one month to kill the parasite. This study will determine if two months of albendazole (ABZ) therapy is better than one-month. The study will last 3 years.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Albendazole
Criteria
Inclusion Criteria:

- Male or female individuals between 18-65 year of age with a diagnosis of basal
subarachnoid cysticercosis, based on MRI and confirmed by serological test.

- Willingness to accomplish the two weeks minimal hospitalization required.

- Female of child-bearing potential willing to use an adequate method of contraception
including implants, injectables, combined oral contraceptives, effective intrauterine
devices, sexual abstinence, or vasectomized partner while participating in the study.

- Patients with normal laboratory values for hemoglobin, platelet counts, total white
blood cells, glucose, creatinine, bilirubin, ALT, AST, and electrolytes.

- Negative fecal exam for Taenia eggs.

Exclusion Criteria:

- Previous therapy with albendazole (does not include patients who received single-dose
400 mg ABZ for intestinal parasites), or praziquantel.

- Pulmonary tuberculosis evidenced by a positive chest X-ray and positive sputum smears.

- Pre-existing diagnosis of diabetes

- Systemic disease other than NCC that may affect therapy or short-term prognosis,
including but not limited to chronic renal failure, hepatic insufficiency, cardiac
failure, and steroid-dependent immune diseases. Identification of systemic diseases
will be left to the discretion of each Site PI.

- Patients in unstable condition or with severe intracranial hypertension (ICH).
Definition of severe ICH for this study would be the presence of headaches, nausea,
and vomiting and papilledema at fundoscopic examination (all of them). Patients in
this category can be considered for entrance into the study only after treatment of
ICH by ventricle-peritoneal shunting. Patients with CT findings compatible with
intracranial hypertension will have neurosurgical evaluation (by non study personal)
before study entry.

- Pregnancy

- History of hypersensitivity to albendazole

- Concurrent treatment with praziquantel, cimetidine or teophylline.

- Chronic alcohol or drug abuse