RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia
Status:
Completed
Trial end date:
2019-05-31
Target enrollment:
Participant gender:
Summary
Men with infertility and normal hormone levels have few options for fertility treatment.
Previous research suggests that men with infertility may have low levels of the active form
of Vitamin A, called retinoic acid, in their testes. In a pilot study of 20 men with low
numbers of sperm (<10 million motile sperm), roughly half the men showed improvement in sperm
production. Thus, we want to see if retinoic acid administration to men with azoospermia (no
sperm present) can initiate sperm production.
Phase:
Phase 2
Details
Lead Sponsor:
University of Washington
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)