Men with infertility and normal hormone levels have few options for fertility treatment.
Previous research work has suggested that men with infertility may have low levels of the
active form of Vitamin A, called retinoic acid, in their testes. We think that giving men
with low sperm counts retinoic acid may increase their sperm counts and improve their chances
of fathering a pregnancy. We want to see if retinoic acid administration over twenty weeks
can increase sperm production and help infertile men become fathers without the need for In
vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). We also want to see
if adding calcitriol with retinoic acid will improve sperm motility in a sub-set of subjects.