Overview R(+)PPX High Dose Treatment of ALS Status: Completed Trial end date: 2009-01-01 Target enrollment: Participant gender: Summary R(+)pramipexole is administered in escalating doses to patients with early ALS. Plasma and spinal fluid levels of R(+)PPX are monitored, in addition to biochemical markers of oxidative stress. Phase: Phase 1/Phase 2 Details Lead Sponsor: Bennett, James P., Jr., M.D., Ph.D.Treatments: Pramipexole