R-ICE Versus R-DHAP in Patients Aged 18-65 With Relapse Diffuse Large B-cell Lymphoma
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to evaluate the efficacy and safety of induction
therapy R-ICE in comparison to R-DHAP after 3 cycles adjusted to successful mobilization of
stem cells in patients with previously treated diffuse large B-cell lymphoma CD20.
The goal is to detect a difference in mobilization adjusted response rate of 15% between
R-ICE and R-DHAP.
The other objective is to evaluate the efficacy and safety of MabThera maintenance therapy
after transplantation as measured by the event free survival.
The goal is to obtain a 15% increase of event free survival at 2 years.