Quetiapine for Delirium Prophylaxis in High-risk Critically Ill Patients

• Status: Completed
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Scheduled, low-dose quetiapine is effective in preventing delirium in high-risk critically ill, trauma/surgical patients. Prophylaxis also reduced ventilator duration and ICU length of stay.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Tennessee Graduate School of Medicine
• Treatments: Quetiapine Fumarate

Criteria

Inclusion Criteria:

• Trauma/surgical patients admitted to the trauma/surgical ICU

Exclusion Criteria:

• sustained RASS of -4/-5 during the complete ICU admission

• presence of a condition preventing delirium assessment

• anticipated or known ICU length of stay of less than 48 hours

• taking antipsychotics prior to admission

• history of schizophrenia, epilepsy, parkinsonism, or levodopa treatment

• primary neurologic event/injury with GCS ≤ 9 during the first 48 hours of ICU

• current treatment with a continuous infusion neuromuscular blocking agent

• pregnancy

• screened positive for delirium upon admission to the ICU.