Studying QoL in patients DLGG receiving TMZ is complex because of the multiples interactions
between tumor characteristics, neurocognitive functioning, treatments, environment and
psychopathological context in which these patients experience symptoms. It is, however,
important to accurately evaluate these aspects in consideration of the young age, generally
preserved QoL at the time of diagnosis, possible implications of the disease on the
professional (DLGG patients are often still active), social and familial domain, and
relatively long survival of these patients. In the absence of a curative treatment for DLGG,
preserving patients' QoL is indeed a major goal.