QL Block With Exparel in Colectomy

• Status: Recruiting
• Trial end date: 2022-01-07
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if using a different type of injection of local anesthestic (pain medicine) in between the muscle layers of the abdominal wall (called a quadratus lumborum block) will improve pain control and be easier to manage after surgery than the current standard of care epidural (spinal injection) pain relief for patients undergoing laparoscopy colectomy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Collaborator: Pacira Pharmaceuticals, Inc
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• Patients scheduled for elective, laparoscopic colonic resection by one of three surgeons: Drs. Thacker, Mantyh or Migaly. These surgeons perform this procedure in the same manner

• Age 18-85 years

• American Society of Anesthesiologists (ASA) Physical Class I-III

• BMI 18-35 kg/m^2

Exclusion Criteria:

• Inability to consent

• Inability to speak English

• Pregnancy

• Emergency surgery

• Contraindications to regional blockade: coagulopathy or bleeding diathesis, local infection, allergy to local anesthetics

• Allergies/intolerances/contraindications to any of the multimodal agents (acetaminophen, gabapentin, ketorolac)

• Daily opioid equivalent use of 30 mg of morphine or greater at time of consent

• History of drug or alcohol abuse

• Rheumatoid arthritis

• Uncontrolled anxiety, schizophrenia or other psychiatric disorder that, in the opinion of the investigator, may interfere with the study assessments of compliance