Pupillometry and Pain Thresholds Patients Substituted by Methadone and Buprenorphine

• Status: Unknown status
• Trial end date: 2013-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose is to study the relation between pupillary diameter measured under scotopic conditions, and the pain thresholds measured at the time of peak and residual effect of methadone/buprenorphine in opiate-dependent patients following a substitution program.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Clermont-Ferrand
• Collaborator: CSAPA ANPAA 63
• Treatments: Buprenorphine; Methadone

Criteria

Inclusion Criteria:

• substitution treatment stable since at least 3 months

• capacity to understand the protocol

• likely to come to visits

• covered by French welfare

Exclusion Criteria:

• chronic pain

• concomitant acute pain

• pregnancy or breast feeding

• relevant mental disease

• peripheral neuropathy

• diabetes

• regular intake of ketamine

• neuroleptic concomitant treatment