Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression
Status:
Completed
Trial end date:
2019-09-03
Target enrollment:
Participant gender:
Summary
Volunteers will receive a weight-based opioid (remifentanil) infusion for 10 minutes. In the
first run, serial pupillary measurements (pupillary unrest, pupil diameter) will be taken at
baseline, and at 2.5-minute intervals during the infusion and a 25-minute recovery period
afterwards. After a washout period, the experiment will be repeated in each subject (second
run). The two runs differ only by presence versus absence of verbal interaction.