Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression

• Status: Completed
• Trial end date: 2019-09-03
• Target enrollment: 0
• Participant gender: All

Summary

Volunteers will receive a weight-based opioid (remifentanil) infusion for 10 minutes. In the first run, serial pupillary measurements (pupillary unrest, pupil diameter) will be taken at baseline, and at 2.5-minute intervals during the infusion and a 25-minute recovery period afterwards. After a washout period, the experiment will be repeated in each subject (second run). The two runs differ only by presence versus absence of verbal interaction.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, San Francisco
• Treatments: Remifentanil

Criteria

Inclusion Criteria:

• Healthy

• Able to provide informed consent

Exclusion Criteria:

• Active substance use disorder

• Prior opioid use disorder

• Opioid use within 30 days.