Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether a combination therapy with angiotensin-converting enzyme (ACE)-inhibitors and angiotensin receptor blockers reduces the arterial stiffness assessed by applantiontonometry more than a single treatment in kidney patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Herlev Hospital
• Treatments: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Candesartan; Candesartan cilexetil; Enalapril; Enalaprilat

Criteria

Inclusion Criteria:

• Creatinine: 150-350 micromol/L

• Blood pressure > 110 systolic

• Negative pregnancy test for fertile women

• Written and oral informed consent from the patient

Exclusion Criteria:

• Treatment with both ACE-inhibitors (ACE-I) and angiotensin receptor blockers

• Pregnancy or breastfeeding

• Treatment with immunosuppressive medication, steroids or non-steroidal anti-inflammatory drugs (NSAIDs)

• Serious chronic heart failure (New York Heart Association [NYHA] III-IV)

• Chronic liver disease

• Suspicion or verified kidney artery stenosis

• Cardiac arrhythmia and/or implanted pacemaker

• Myocardial infarction or cerebrovascular incidence within the last 3 months

• Allergy towards ACE-I or angiotensin receptor blockers

• Amputation of a whole extremity or the crural or femoral part of the leg

• Dementia or a psychological condition that makes understanding of the examination conditions impossible

• Dialysis or renal transplantation

• Treatment with aldosterone antagonists

• Hyperkalemia > 5.5 mmol/l

• Another serious chronic non-renal disease