The purpose of this study is to explore the effects of synthetic gonadotropin-releasing
hormone (GnRH) upon the pituitary and ovaries of women with infertility. Women diagnosed with
GnRH deficiency, hypothalamic amenorrhea or acquired hypogonadic hypogonadism, will
participate in this study. It is hoped that administration of GnRH will lead to proper
stimulation of the pituitary gland and to normal ovulation and menstruation.
**WE ARE CURRENTLY RECRUITING ONLY WOMEN WITH A DIAGNOSIS OF IDIOPATHIC HYPOGONADIC
HYPOGONADISM (IHH)**
Pulsatile GnRH has been approved by the FDA for use in women with primary amenorrhea due to
complete GnRH deficiency. The overall goals of this protocol are to continue to use pulsatile
GnRH in GnRH-deficient and other anovulatory women for ovulation induction and to examine
specific physiologic hypotheses, which can only be addressed in this patient population.
Phase:
Phase 2
Details
Lead Sponsor:
Massachusetts General Hospital
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)