: Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
Status:
Unknown status
Trial end date:
2018-06-30
Target enrollment:
Participant gender:
Summary
Anesthetics with vasoconstrictors decrease pulpal blood flow but the impact of intranasal
local anesthetics on blood flow is unknown. This blinded, randomized crossover clinical trial
will compare the effects of different local anesthetics on anterior teeth in healthy
volunteers. On separate study visits patients will receive either traditional injections or
intranasal administration of the following solutions: 2% lidocaine with 1:100,000 epi, 3%
mepivacaine, tetracaine HCl and oxymetazoline HCl, or saline. The following variables will be
assessed: pulpal blood flow, pulpal sensibility, pain on administration, and adverse
outcomes.
Phase:
Phase 4
Details
Lead Sponsor:
Louisiana State University Health Sciences Center in New Orleans