Pubertal Induction in Individuals With Hypogonadism

• Status: Unknown status
• Trial end date: 2020-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators wish to explore the variability of uterine, breast and bone outcome markers as surrogates to assess the adequacy of exogenous oestrogen replacement in individuals with hypogonadism.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University College, London
• Treatments: Estrogens

Criteria

Inclusion Criteria:

1. Have a diagnosis of hypogonadism (Turner's syndrome, hypogonadotrophic hypogonadism, primary ovarian insufficiency, hypopituitarism, hypothalamic amenorrhoea, transgender)

2. ≥ 10 years of age

3. Oestrogen naïve i.e. no prior commencement of oestrogen treatment

4. Breast Tanner stage ≤ than 2

Exclusion Criteria:

1. Previous oncology treatment

2. Primary amenorrhoea secondary to chronic medical comorbidity

3. PCOS diagnosis