Psychopharmacological Treatment of Emotional Distress
Status:
Recruiting
Trial end date:
2026-10-01
Target enrollment:
Participant gender:
Summary
This is an inpatient four-arm randomized control trial comparing single drug clonazepam (S
arm), a two-drug combination clonazepam/olanzapine (D arm), and a three-drug combination
clonazepam/olanzapine/buprenorphine (T arm) with treatment as usual (TAU arm) in the
treatment of emotional distress, specifically the Suicide Crisis Syndrome (SCS). All
participants in experimental arms receive 2-day pulse treatments targeting four out of five
of the acute emotional distress symptoms. The primary outcome measure is SCS at discharge and
one-month follow-up. The secondary outcome measures include questions about suicidal
behaviors associated with emotional distress at a one-month follow-up.