The purpose of this study is to investigate the effects of oral psilocybin in migraine
headache. Subjects will each receive a dose of placebo and a dose of psilocybin approximately
14 days apart. Subjects will be randomized to the order of treatment and they will be
randomized to receive either low or high dose psilocybin. Subjects will maintain a headache
diary prior to, during, and after the treatments in order to document headache frequency and
intensity, as well as associated symptoms. This preliminary study will inform on the basic
effects of psilocybin in migraine headache and inform on the design of larger, more
definitive studies.