The purpose of this study is to investigate the effects of an oral psilocybin pulse regimen
in cluster headache. Subjects will be randomized to receive oral placebo, low dose
psilocybin, or high dose psilocybin in three experimental sessions, each separated by 5 days.
Subjects will maintain a headache diary prior to, during, and after the pulse regimen in
order to document headache frequency and intensity before, during, and after the pulse
regimen. After at least 6 months from the last experimental session, subjects may be invited
for a second round, in which they will be randomized to receive either low dose or high dose
psilocybin.
Phase:
Phase 1
Details
Lead Sponsor:
Yale University
Collaborators:
Cluster Headache-Trigeminal Autonomic Cephalalgia (CH-TAC), LLC Heffter Research Institute