The primary purpose of this study is to evaluate the feasibility and estimate the efficacy of
psilocybin-facilitated treatment for cocaine use. We also will monitor the impact of
psilocybin-facilitated treatment on the use of other drugs and outcomes relevant to cocaine
involvement (e.g., criminal involvement).
MRI assessment is a unique aspect of this study. As a potential biological mechanism of
psilocybin's effect includes changes in default mode network functional connectivity
(Carhart-Harris et al., 2012), we will determine if psilocybin's therapeutic effects are
mediated by such changes. Moreover, as Glx (a brain metabolite that reflects glutamate)
abnormalities have been shown to play a role in cocaine addiction, we will determine if
psilocybin impacts Glx in the anterior cingulate cortex and hippocampus.