Overview

Psilocybin Therapy for Chronic Low Back Pain

Status:
Not yet recruiting
Trial end date:
2024-12-01
Target enrollment:
0
Participant gender:
All
Summary
This study evaluates whether psilocybin therapy helps patients cope with chronic low back pain more effectively. Patients may be recruited at Stanford and University of California San Francisco (UCSF), study procedures will occur at UCSF. Each participant will receive a dose of psilocybin with possibly one or more other drugs. Participants will undergo two preparation sessions, a dosing session, three integration sessions to discuss their psilocybin experience, and several follow up sessions.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Joshua Woolley, MD/PhD
Treatments:
N,N-Dimethyltryptamine
Psilocybin
Criteria
Inclusion Criteria:

- Age 25 to 70 years old

- Comfortable speaking and writing in English

- Diagnosed with chronic low back pain

- Able to attend all in-person visits at UCSF as well as virtual visits

- Has tried at least two previous medications/ procedures and physical therapy trials
for low back pain

Exclusion Criteria:

- Chronic low back pain that is attributed to malignancy, subacute or acute fracture or
infection

- Low back pain with radiation below the knee

- Low back pain with neurologic signs present

- Regular use of medications that may have problematic interactions with psilocybin,
including but not limited to dopamine agonists, MAO inhibitors, antipsychotics, and
stimulants

- A health condition that makes study unsafe or unfeasible, determined by study
physicians