Overview

Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis

Status:
Terminated
Trial end date:
2019-12-31
Target enrollment:
0
Participant gender:
All
Summary
Proton pump inhibitor plus propranolol versus proton pump inhibitor alone on peptic ulcer healing in patients with liver cirrhosis: a randomized trail
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Taipei Veterans General Hospital, Taiwan
Treatments:
Propranolol
Proton Pump Inhibitors
Rabeprazole
Criteria
Inclusion Criteria:

- Between 20 and 85 years old

- Liver cirrhosis associated with esophageal varices or gastric varices

- Gastric ulcer or duodenal ulcer ,size bigger or egual than 0.5 cm

Exclusion Criteria:

- Acute bleeding

- Steroid or NSAID user

- Pregnancy, or the patients with other terminal illness (such as other terminal
cancers, heart failure, renal failure...)

- Propranolol contraindications (such as atrioventricular block, heart failure, chronic
obstructive pulmonary disease, asthma, poorly controlled diabetes, severe peripheral
arterial disease...)