Protocol of Diuretics Use in Congestive Therapy in Heart Failure

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The main objective of the study is to determine if a diuretic adaptation protocol in the decompensation of chronic heart failure is more effective but also safer than the current non-protocolized practice.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Clermont-Ferrand
• Collaborators: Centre Hospitalier Annecy Genevois; CH Annecy Genevois; CH Issoire; CH Montluçon; CH Moulins-Yzeure; CH Puy en Velay; CH Riom; Hôpital de la Croix-Rousse; Hospices Civils de Lyon; Infirmerie Protestante de Lyon; University Hospital, Grenoble
• Treatments: Diuretics; Furosemide; Hydrochlorothiazide; Sodium Potassium Chloride Symporter Inhibitors

Criteria

Inclusion Criteria:

• Adult patients hospitalized for chronic decompensated congestive heart failure without acute pulmonary edema and acute cardiac decompensation against a background of hypertensive crisis

• covered under a social security program

• with legal capacity to give voluntary informed consent to participate in the study

Exclusion Criteria:

• First episode of decompensated congestive heart failure

• Protocolized shock or hypotension (<90 mmHg blood pressure) managed or requiring nitrovasodilators or non-invasive ventilation

• One of the following cardiovascular pathologies: acute myocardial infarction / cardiac tamponade / aortic dissection / acute pulmonary embolism / heart transplant / ventricular assist device / acute pulmonary edema / hypertensive crisis

• More than 12h of intravenous diuretics administered prior to inclusion

• Generalized edema caused by cirrhosis or nephrotic syndrome

• Requiring pleural or peritoneal tap for therapeutic purposes

• Patient allergic or intolerant to furosemide and on long-term bumetanide use

• Patient in dialysis or end-stage chronic kidney disease (CKD-EPI-calculated GFR <15 mL/min/1.73m²) or acute kidney injury of known non-cardiac cause

• Severe hypokalemia (< 3 mmol/L) on admission

• Patient who is pregnant, breastfeeding, or of childbearing age not on effective contraception

• Adult patient safeguarded under court protection measures (guardianship, wardship, or judicial protection)