Protein Profile of Immunoregulatory Factors in Diabetic Cataract

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the levels of several immunoregulatory factors in serums and aqueous humor of type II diabetes cataract patients with those in senile non-diabetic cataract patients since disturbed cytokine and growth factor microenvironment in diabetic eye may contribute to an increased frequency of intraoperative and postoperative intraocular lens surgery complications.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Zagreb
• Treatments: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Ketorolac; Ketorolac Tromethamine

Criteria

Inclusion Criteria:

• patients undergoing phacoemulsification combined with IOL implantation

• for diabetic group: duration of type 2 diabetes mellitus (T2DM) for 10 to 15 years

• for diabetic group: therapy with oral hypoglycemic agents for glycemic control

• no other ocular (retinal) or systemic diabetic complications of T2DM

Exclusion Criteria:

• patients who had cataract that could result from some other ocular condition, systemic disease (except T2DM for diabetic group) or trauma

• patients with immune disease, local or systemic inflammation which could affect cytokine concentration in serum or aqueous humor (AH)