Protective Role of N-acetylcisteine From Cisplatin-induced Ototoxicity in Patients With Head and Neck Cancer
Status:
Completed
Trial end date:
2017-11-01
Target enrollment:
Participant gender:
Summary
Introduction. Cisplatin-induced ototoxicity is a very frequent event and its consequences can
cause a lot of deterioration in patients. Early diagnosis is essential because it would allow
the appropriate implementation of strategies to reduce its effect. Among these
N-acetylcysteine, an antioxidant agent that has shown otoprotective effect. Study design.
Randomized, parallel design and placebo controlled clinical trial. Methods. Patients with
head and neck cancer who require treatment with cisplatin were enrolled in 2 branches: a
control group that receives a placebo and experimental group that receives the drug.
High-frequency audiometries (6 - 16 KHz) are performed before, during and after the treatment
finalization.