Protective Effects of EPI-743 on Noise-Induced Hearing Loss

• Status: Completed
• Trial end date: 2016-02-29
• Target enrollment: 0
• Participant gender: All

Summary

If effective, administration of EPI-743 should have protective effects against temporary noise-induced hearing loss.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Edison Pharmaceuticals Inc
• Treatments: Ubiquinone

Criteria

Inclusion Criteria:

• Healthy adults ages 18-30

• Abstention from use of Idebenone, CoQ10, Vitamin E and foods or beverages at least 30 days prior to treatment initiation

• Non-smokers

• Abstention from alcohol from day 0 and throughout the duration of study

• Normal audiology exam

• Subject must be able to swallow size 0 capsules

Exclusion Criteria:

• Allergy to EPI-743 or sesame oil or nuts

• Any medical disordere that would prevent subject participation

• Any prescription meds other than for contraception or seasonal allergies

• Any significant patient medical history (cancer, cardiovascular, pulmonary, cognitive, ADHD, hx. of migraines, neurological, kidney)

• Fat malabsorption syndromes

• Anticoagulation thereapy within 30 days of enrollment