Protective Effect of Zingiber Officinale L. Extract in Hypertensive Patients
Status:
Completed
Trial end date:
2018-06-30
Target enrollment:
Participant gender:
Summary
Hyperlipidemia is a well-known risk factor for cardiovascular diseases (CVDs). Coronary heart
disease, stroke, and atherosclerosis are among the primary cause of death. Various medicines
are available for the treatment of hyperlipidemia however, they are linked with serious
unwanted effects. Zingiber officinale L. extract (Ginger) was used in folklore medicine as a
hypolipidemic agent, Although, its clinical trial studies were not been investigated in the
Pakistani population yet. Our clinical study is the first to assess the hypolipidemic,
antioxidant, and cardioprotective effect of ginger tablets on dyslipidemic patients regarded
as important risk factors for cardiovascular morbidity. A total of 40 dyslipidemic patients
of age (18-65 years) of either sex were recruited in Al-Khidmat Hospital Karachi and
allocated into two groups; the Simvastatin group (20 mg OD) and the Ginger treated group
(500mg Ginger tablets BD) for 2 months. At baseline, their Blood pressure (BP), heart rate
(HR), Insomnia severity index (ISI), Minimental state examination (MMSE), Lipid profile,
Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT),
creatine kinase (CK-MB), C-reactive protein, Superoxide Dismutase (SOD) & Glutathione
Peroxidase (GPx) were recorded and repeated after 2 months of follow-up.
Phase:
Early Phase 1
Details
Lead Sponsor:
Jinnah Sindh Medical University
Collaborators:
Al Khidmat Hospital Nazimabad Karachi Medics Laboratories (Pvt.) Ltd.