Protective Effect of Beraprost Sodium Tablets on Reperfusion Therapy for Acute STEMI

• Status: Recruiting
• Trial end date: 2023-06-30
• Target enrollment: 0
• Participant gender: All

Summary

Protective effect of Beraprost Sodium Tablets on coronary microcirculation function and ventricular remodeling after reperfusion therapy for acute ST segment elevation myocardial infarction

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shenzhen People's Hospital
• Treatments: Beraprost

Criteria

Inclusion Criteria:

• It meets the diagnostic criteria of acute ST segment elevation myocardial infarction:

① ischemic chest pain lasts for more than 30 minutes and can not be relieved by taking nitroglycerin; ② ST segment elevation of ECG with two or more adjacent leads, limb lead ≥ 1mm, chest lead ≥ 2mm; Or new left bundle branch block; ③ The serum markers of myocardial necrosis increased at least twice the normal value

• Acute myocardial infarction was confirmed by coronary angiography

• The clinical and angiographic data were complete

• Direct PCI was performed within 12 hours after onset

Exclusion Criteria:

• Those who do not cooperate in the inspection, have poor compliance and cannot guarantee the completion of the test

• Conscious disorder, obvious intellectual disorder and mental disorder

• With metal foreign bodies, such as metal prosthesis, intraocular metal foreign bodies, intracranial aneurysm clamp, etc

• People with claustrophobia

• Had a history of myocardial infarction, PCI and coronary artery bypass grafting

• Factors affecting ST segment changes of ECG: complete left bundle branch block, preexcitation syndrome, pacemaker ECG, etc