Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether doxycycline (Periostat) at a sub-antimicrobial dose will decrease reperfusion injury after coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Alberta
• Treatments: Doxycycline

Criteria

Inclusion Criteria:

• Written informed consent

• Aged 18 through 80 years, inclusive

• Scheduled for primary CABG surgery with CPB

Exclusion Criteria:

• Females of childbearing potential

• Emergency CABG

• Previous sternotomy

• Planned simultaneous surgery (i.e. valve repair or carotid endarterectomy)

• Myocardial infarction within 48 hours

• Pre-operative atrial fibrillation

• Pre-operative ventricular pacing or left bundle branch block (LBBB)

• Known hypersensitivity to tetracycline class antibiotics

• Renal failure requiring dialysis