Protection Against Insulin Resistance in Obesity

• Status: Active, not recruiting
• Trial end date: 2026-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The overall goal of this project is to identify factors that "protect" some obese adults from becoming insulin resistant. Identifying mechanisms that help protect some obese adults from developing insulin resistance could lead to novel, targeted therapeutic and/or preventative strategies for obese adults who are insulin resistant.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Michigan
• Treatments: Insulin

Criteria

Inclusion Criteria:

• Body mass index [BMI]: 30-40 kg/m2

• Age: 18-45 years

• All women must be pre-menopausal

• Non-exerciser: no regularly planned exercise/physical activity

Exclusion Criteria:

• Weight instability ≥ ±3kg ≥ 6 months

• Medications known to affect lipid and/or glucose metabolism

• Pregnancy or actively breast feeding