Prospective Validation Of The Eleveld TCI Model For Propofol In The Malaysian Obese Population
Status:
Not yet recruiting
Trial end date:
2025-12-31
Target enrollment:
Participant gender:
Summary
This is a prospective single blinded randomized trial to validate the 2014 published and
widely used Eleveld TCI model which is a universal model suitable for use in all age groups
and is suitable for all patients even in the extremes of weight.
This study involves 36 patients who meet the inclusion and exclusion criteria that have been
set. Once consent obtained patients will undergo surgery utilizing total intravenous
anaesthesia via the target control infusion method and plasma levels of propofol will be
sampled sequentially for 1 hour during surgery and analysed to compare the difference between
the set and measured level of propofol in plasma. From this data obtained the median absolute
prediction error calculated. The secondary goal of this study is to assess the BIS-Propofol
correlation in the obese population as well as the hemodynamic stability of this particular
model in the obese population.
The data from this study will allow a more targeted anaesthetic approach in the obese
population and prevent morbidities in our future practice.