Prospective Study of Methicillin-Resistant Staphylococcus Aureus (MRSA) Among HIV-Infected Persons

• Status: Completed
• Trial end date: 2017-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will prospectively evaluate the prevalence and incidence (over a two year period) of MRSA colonization and infection among HIV-infected military beneficiaries to determine predictors for the development of MRSA colonization and infection. This study will also investigate the utility of decolonization procedures for clearance of MRSA carriage and prevention of MRSA infections. Finally, the molecular characteristics and the antimicrobial sensitivities of isolates in this population will be determined.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Uniformed Services University of the Health Sciences
• Collaborators: Infectious Diseases Clinical Research Program; National Institute of Allergy and Infectious Diseases (NIAID); US Military HIV Research Program
• Treatments: Hexachlorophene; Methicillin; Mupirocin; Triclosan

Criteria

Inclusion Criteria:

• Adults (at least 18 years of age) who are HIV positive by a reactive screening (ELISA, EIA) and a confirmatory test (Western blot) and who are able to attend the study visits which are every 6 months (+/- 2 months), at the minimum

Exclusion Criteria:

• Known allergy to mupirocin (Bactroban®) nasal ointment or hexachlorophene (pHisoHex®) soaps or constituents of these products.

• Age less than 18 years.

• Inability to remain in the study for the two year duration.

• Pregnant or breastfeeding females.

• Females who intend to become pregnant during the two year study time period.

• Persons who are healthcare providers with direct patient contact.