Prospective Study of Fertility-sparing Treatment Strategy in Patients With Early Cervical Cancer(SYSUGO-005/CSEM009)
Status:
Recruiting
Trial end date:
2025-11-01
Target enrollment:
Participant gender:
Summary
Patients with cervical cancer staging IB1-IIA2 desiring keeping their fertility function will
be recruited. Before treatment, MRI scanning will be used to exclude retroperitoneal lymph
node metastasis, involvement of lower part of uterus and endometrial carcinoma.If there is no
macroscopic tumor and no obvious disease in MRI,simple trachelectomy (ST) + sentinel lymph
node biopsy (SLNB) / retroperitoneal lymph node dissection(RPLND) will be performed.
Otherwise,two to three cycles of neoadjuvant chemotherapy (NACT) will be administrated and
then different fertility-sparing surgery(conization,ST or radical trachelectomy(RT) +
SLNB/RPLND) will be employed depending on the tumor size.