Prospective Randomized Trial of Bactrim on 7 Day Outcome in Patients With Uncomplicated Abscesses
Status:
Completed
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
Patients will be enrolled in a multi-center study to prospectively evaluate outcome after
treatment for an uncomplicated skin abscess. All patients will receive incision and drainage
and wound cultures. Patients will then be randomized to 1) placebo two tablets PO BID X 7
days or 2) bactrim DS (800/160) two tablets PO BID x 7 days. Patients will then return to the
emergency department ED) at 48 hours and 7 for wound repacking and evaluation. The primary
outcome is treatment failure rates at 7 days after incision and drainage. Patients who are
clinically worsening or not improving after 48 hours will then be treated with additional
antibiotics or admission if needed. Data will be analyzed both by initial randomization and
intention to treat.