Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
The Department of Anesthesiology is conducting a clinical trial to evaluate if pregabalin
given prior to and for several days after Total Knee Arthroplasty (TKA) will reduce the
prevalence of Complex Regional Pain Syndrome (CRPS) at late postoperative times. The
prevalence of complex regional pain syndrome (CRPS) following total knee arthroplasty (TKA)
is 13% at 6 months post-surgery. CRPS is a painful debilitating condition, with 4 main
classes of symptoms : sensory, including burning, allodynia, and hyperalgesia in the affected
limb; vasomotor, including temperature asymmetry and skin color changes; edema and sudomotor,
including sweating; and movement disorders and dystrophy, including decreased range of
motion, motor dysfunction (weakness, tremor, dystonia) and changes in hair, nails or skin.