Propranolol in Severely Burned Children

• Status: Terminated
• Trial end date: 2019-04-23
• Target enrollment: 0
• Participant gender: All

Summary

To determine the safety and efficacy of administration of propranolol for reducing heart rate and blood pressure in burn injury.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Medical Branch, Galveston
• Collaborator: Shriners Hospitals for Children
• Treatments: Metoprolol; Propranolol

Criteria

Inclusion Criteria:

• Burns covering >20% of the total body surface are

• Age of 0 to 18 years

• Patient arrival to the burn center within 96 hours (4 days) of burn injury

• Require > 1 surgical procedure

Exclusion Criteria:

• Pregnancy

• Known history of AIDS, Aids Related Complex, or HIV

• History of cancer within 5 years

• Existence of pre-morbid conditions

• Asthma

• Congestive heart failure (measured ejection fraction < 20%)

• Medical condition requiring glucocorticoid treatment

• Burn injury due to chemical burns

• Burn injury due to deep electrical injury (decision of hospital PI)

• Presence of anoxic brain injury that is not expected to result in complete recovery

• Decision not to treat due to burn injury severity