Propofol vs Sevoflurane in Cyanotic Congenital Heart Disease
Status:
Recruiting
Trial end date:
2021-11-01
Target enrollment:
Participant gender:
Summary
The stress response to surgery compromises a series of humoral, metabolic, or cellular
reactions. Cardiac surgery with use of cardiopulmonary bypass (CPB) is a major activator of
the systemic inflammatory response (SIRS). Inflammation, resulting in neutrophil activation,
plays a central role in the production of reactive oxygen species (ROS). Inflammatory and
oxidative reactions may play a role in the more frequent observation of postoperative
ventricular dysfunction in patients with cyanotic congenital heart disease (CHD) undergoing
surgery. The aim of this study is to compare the anti-inflammatory and anti-oxidative effects
of propofol and sevoflurane in children with cyanotic CHD undergoing open heart surgery with
CPB.