Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus Surgery
Status:
Unknown status
Trial end date:
2020-02-01
Target enrollment:
Participant gender:
Summary
Endoscopic Sinus surgery usually associated by bleeding, despite using of local vasopressor
injection, head up position- controlled hypotension is generally used for control of this
purpose.
Propofol has been reported as a good agent for controlled hypotension by decreasing systemic
vascular resistance secondary to arterial and venous vasodilation and a decrease in
myocardial contractility with a dose-dependent property.
Magnesium Sulfate also has been reported as an agent of hypotensive anaesthesia by inhibition
of the release of norepinephrine by blocking N-type calcium channel at the nerve ending
beside acting as a vasodilator.
The well known pharmacodynamic effects of the intravenous infusion of propofol or Magnesium
Sulfate may prove the advantage of this group in controlling intraoperative blood pressure
thus reducing surgical field bleeding.