Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy
Status:
Completed
Trial end date:
2018-07-19
Target enrollment:
Participant gender:
Summary
An ideal sedative for colonoscopy should have properties that include: rapid onset and offset
of action, provide cardiopulmonary stability, have minimal adverse effects, and allow for
smooth recovery, and early discharge. Propofol is often used solely because of its rapid
onset and short duration of action---a property which is ideal for a fast recovery and early
discharge in the ambulatory setting. However, the use of propofol has been associated with
undesirable effects such as hypotension, hypoventilation and apnea requiring assisted
ventilation.
Balanced anesthesia, using a combination of medications with different mechanisms of action
can reduce the total amount of each sedative agent used and minimize their side effects while
achieving the desired level of sedation. Dexmedetomidine is one agent that has been used
either alone or in combination with propofol for sedation during colonoscopy. While there are
many advantages to using dexmedetomidine, there is concern that the use of this agent for
sedation during colonoscopy may prolong post-operative recovery time and readiness for
discharge home.
No study has definitively assessed whether the use of dexmedetomidine in combination with
propofol during ambulatory colonoscopy prolongs post-operative recovery time as determined by
the Modified Post Anesthesia Discharge Scoring System (MPADSS).
Phase:
Phase 4
Details
Lead Sponsor:
State University of New York - Downstate Medical Center