Propofol Pharmacokinetics and Pharmacodynamics Modelling
Status:
Completed
Trial end date:
2017-04-28
Target enrollment:
Participant gender:
Summary
The main purpose of this research is to develop a population pharmacokinetic and
pharmacodynamic model of Propofol when used for induction and maintenance of anaesthesia,
using BIS as a pharmacodynamic endpoint.
A covariate analysis will be performed in order to account for variability in pharmacokinetic
and pharmacodynamic parameters. The influence of age and obesity on propofol pharmacokinetic
parameters will be particularly addressed.