Propofol-Ketamine vs Remifentanyl-Ketamine for Sedation in Pediatric Patients Undergoing Colonoscopy
Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
Ketamine and propofol have been used most frequently agents and remifentanil is used with
increasing frequency in recent years. Investigators will compare ketamine-propofol and
ketamine-remifentanyl effects on drug consumption, respiration, hemodynamics and recovery in
pediatric colonoscopy patients. Our study is a prospective, randomized comparison of
ketamine-propofol and remifentanyl-propofol for sedation in pediatric patients during
elective colonoscopy. ASA I-II, 2-16 years old, seventy children will be included in the
study after ethics committee approval and written informed consent from the parents. Children
with cardiovascular, cerebral, pulmonary, renal and hepatic diseases will be excluded from
the study. Group I (RK); 2 mg/kg ketamine and 0,25 µg/kg remifentanyl will be administered
for induction in 1 minute.Then 0,1 µg/kg/h remifentanyl infusion will be started.
Group II (PK); 2 mg/kg ketamine and 1 mg/kg propofol will be administered for induction and
then 1 mg/kg/h propofol infusion will be started. In case of movement, crying, heart rate and
systolic blood pressure more than 20% increase from baseline; 0.05 to 0.1 mg / kg of
remifentanil will be administered in group I, 0.5-1 mg / kg will be administered propofol in
group II. Not enough that case 0.5-1 mg / kg of ketamine will be applied.
The anesthesiologist will continue monitoring after completion of colonoscopy until recovery
of full consciousness. A Steward recovery score of 7 will be defined as the end of the
recovery time.